Ubiquinol ameliorates endothelial dysfunction and increases expression of miRNA-34a in a rat model of pulmonary hypertension

Introduction: In this research, we evaluate the effect of intravenously administrated solubilized ubiquinol on 4-week monocrotalin-induced pulmonary hypertension (PH) in rats.
 Materials and methods: To reproduce model, some male Wistar rats were subcutaneously injected with alcohol solution monocrotaline60 mg/kg rest – (Control). Those monocrotaline (MCT) divided into 3 groups. They underwent intravenous administration 1% 30 (MCT-Ubiquinol), vehicle (MCT-Vehicle) saline (MCT-saline) three times days 7, 14 21, depending group. The hemodynamic parameters measured anesthetized day 29. Right ventricle hypertrophy, arteries reactivity expression miRNA-21 miRNA-34a estimated after euthanasia.
 Results discussion: All MCT-groups demonstrated an increase right systolic pressure hypertrophy comparison control An lung weight was shown MCT-Vehicle MCT-Saline; however, MCT-Ubiquinol indicators did not differ from those Control. There increased vasodilatation response to acetylcholine at concentrations 1*10-6M 1*10-5M contrast other two MCT-groups. A significantly lower level observed MCT-Ubiquinol.
 Conclusion: Our findings suggest that a triple injection influences changes endothelium-depended vasodilatation, which contributes vascular tone reactivity. decrease group demonstrates anti-inflammatory properties.